Dodgers vs Giants Prediction, Betting Odds, and Our Best Bet for Saturday Night’s NL West Clash

Tonight’s matchup between the Los Angeles Dodgers and San Francisco Giants carries big weight in the NL West race, and it’s the final series before the All-Star break. The Dodgers have stumbled into the weekend with 7 straight losses, while the Giants are red-hot, winning 4 out of their last 5 games, including a wild 8-7 win in Game 1 of this series just last night.

Game Details and Pitching Matchup

The Dodgers hand the ball to Shohei Ohtani, making just his 5th pitching start of the season. His debut on the mound in 2025 was a short but effective one — 6 innings total so far this year, with just a single earned run, a 0.83 WHIP, and 6 strikeouts. He tossed 2 clean innings in his last outing against Houston, allowing just one hit and striking out 3. His command looked sharp, and he got through 31 pitches without much stress. The Dodgers are obviously easing him back into the role on the bump.

For San Francisco, Landen Roupp takes the mound. Roupp is 6-5 on the year with a 3.39 ERA and a 1.46 WHIP over 90.1 innings. He’s pitched well in recent starts where he gave up just 3 runs in 9 innings across two outings this month — but there’s a red flag here — the last time Roupp faced the Dodgers, he gave up 6 earned runs in just 1.2 innings. That June 14 start was one of his worst, and it came against nearly the same lineup he’ll see tonight.

The ballpark, Oracle Park in San Francisco, tends to favor pitchers. It’s averaging just 8 total runs per game this season, and the under has hit in 27 of the 46 games played there. That’s telling and that might seem to point toward a low-scoring game, but the Dodgers’ offense changes that calculus. We could see fireworks with this game like we did last night.

Odds and Betting Lines

The Dodgers are -165 favorites on the moneyline, with a run line of -1.5 at +100. The Giants are priced at +135 to win outright, and they’re +1.5 on the run line at -122. The over/under total is set at 8.5, with the under at -114 and the over at -106.

Oddsmakers are still favoring L.A. despite the losing streak, and that’s largely due to the pitching edge with Ohtani and the Dodgers’ lineup depth. It’s easy to see why the Dodgers have that sharp of a line.

Analysis and Prediction

There’s no question the Dodgers are in a funk as they’ve dropped 7 in a row, including 2 heartbreaking one-run losses and a walk-off. But despite the slide, this is a team that still leads the league in runs scored with 836, home runs with 144, OBP at .333, and slugging at .449. Their offense isn’t the problem as they’ve scored 7, 3, and 3 in their last 3 games, but the bullpen and defense have let them down. The bats are hot, but they need the rest to pull their weight.

On the other hand, the Giants rank just 25th in batting average at .232 and 21st in runs per game at 4.2. Sure, they’ve found ways to win with pitching lately, but the offense remains inconsistent. Heliot Ramos has been their best bat, hitting .265 with 14 homers and 47 RBIs. Beyond that, it’s been a patchwork lineup. They’ll need their bats to come alive tonight if they’re going to win this series.

That’s where Roupp’s matchup becomes a concern. While his recent outings against Philly and Arizona were solid, he’s shown vulnerability against high-powered teams. That 1.2-inning meltdown versus L.A. earlier this season looms large. And it wasn’t just a bad day — Roupp was clearly rattled by the Dodgers’ approach, and it’s hard to see him flipping the script here, especially since the Dodgers are hungry to break this streak.

The Dodgers still have the edge in nearly every team stat: they’re hitting .258 as a team (5th), while San Francisco is at .232 (25th). L.A.’s lineup features Shohei Ohtani who has 32 HR, 60 RBI, a .278 AVG, and Will Smith (.328 AVG, .429 OBP, .549 SLG), 2 of the most consistent bats in baseball this year. Ohtani also thrives in Oracle Park conditions — it’s one of the few pitcher-friendly parks that doesn’t kill his power due to his opposite-field strength.

One thing we think is worth noting — Ohtani likely won’t go more than 2-3 innings again. So, don’t get too hung up with him on the bump. The Dodgers will need 6+ innings from their bullpen, which hasn’t exactly been lights-out lately. But their offense gives them more margin for error than San Francisco, especially with a shaky Giants pen that’s been stretched this week due to multiple close games and extra-inning finishes.

The Dodgers also know this is their last chance to head into the break with a win and avoid a full-blown collapse. They’re way too talented to keep losing games like this.

Dodgers vs Giants Prediction

The best value lies on the Dodgers moneyline at -165. Yes, it’s fairly juiced, but it’s backed by a superior lineup, a pitching edge with Ohtani, and a desperation factor that simply can’t be overstated. If you’re hunting plus money, take a look at the Dodgers -1.5 at +100, especially given Roupp’s struggles against this team. But straight-up, the moneyline is the safer, more reliable option.

• Final Score Prediction: Dodgers 6, Giants 3
• Best Bet: Los Angeles Dodgers moneyline at -165

We think that the Dodgers’ bats break out, Roupp struggles again, and L.A. heads into the break with at least a win.