Best NFL DFS Picks for Monday Night Football: Giants vs Rams DraftKings Lineup

Monday Night Football closes out Week 2 with the Giants heading to SoFi Stadium to take on Sean McVay’s Rams, and this single-game slate has more juice than the standard MNF matchup. New York enters 1-0 off a statement win over Dallas, while Los Angeles is looking to bounce back after dropping its opener. The Rams are favored by around 9.5 points with the total sitting near 48.5, meaning game script is going to swing DFS value in a big way tonight.

On a limited-game slate like this, correlation matters more than usual. You want exposure to both offenses, a clear read on who benefits if the game turns into a shootout versus a blowout, and salary discipline since there’s no other slate to diversify into. Here are five NFL DFS picks worth building around for tonight’s DraftKings lineup and FanDuel builds.

Jaxson Dart, QB — New York Giants ($9,800 DK)

Dart was close to perfect in his first career start, completing 23 of 29 passes for 230 yards and three touchdowns in the Giants’ 28-20 win over Dallas. He didn’t turn the ball over once, converted 9 of 10 third downs, and added 54 rushing yards on 11 carries — more than half of those were designed runs in Matt Nagy’s scheme, which is exactly the kind of rushing floor that makes a quarterback a cash-game safety net and a tournament ceiling play at the same time.

Facing a Rams defense on the road against a 9.5-point spread sounds like a tough ask, but that game script actually helps Dart’s DFS profile. If New York falls behind, Nagy will lean on his rookie’s arm, and Dart already has rapport with Isaiah Likely and Malik Nabers in the passing game. At $9,800, he’s not cheap, but he’s the centerpiece of nearly every winning MNF DFS lineup build tonight given his rushing upside on top of a real passing floor.

Cam Skattebo, RB — New York Giants ($9,400 DK)

Skattebo was the clear lead back in Week 1, playing 41 of 63 offensive snaps (61% share) and out-touching Devin Singletary and Tyrone Tracy Jr. combined. He carried 18 times for 81 yards and a touchdown, opening the scoring with a 3-yard score on New York’s first possession. The one blemish: zero targets, which caps his ceiling somewhat in a game where the Giants could be playing from behind.

Facing the Rams’ run defense, Skattebo still projects as the early-down and goal-line back regardless of script, and that volume alone makes him playable at this price. He’s not the safest bet if New York trails big and abandons the run, but his touch floor as the clear RB1 in a backfield that already gave him 18 carries in Week 1 makes him a reasonable piece of a Monday Night Football DFS build, especially in cash games where volume matters more than upside.

Kyren Williams, RB — Los Angeles Rams ($9,600 DK)

Williams didn’t have his best game in the season opener, managing just 41 yards on 11 carries, but he still found paydirt on Los Angeles’ lone touchdown and added 24 yards on three catches. Context matters here: from 2023 through 2025, Williams topped 1,350 yards from scrimmage with double-digit touchdowns every single year, and a quiet Week 1 shouldn’t erase that track record heading into a home game as a heavy favorite.

With the Rams favored by roughly 9.5 points, game script tilts heavily toward positive work for their lead back — more carries, more goal-line looks, and likely a garbage-time role in the passing game if the lead balloons. Against a Giants front that struggled to slow down the run in spots last week, Williams profiles as one of the safer floor-plus-ceiling combinations on the entire slate, and he’s a strong pivot away from the more popular Rams passing-game pieces.

Malik Nabers, WR — New York Giants ($9,000 DK)

Nabers made his long-awaited return from a torn ACL in Week 1 and looked the part, catching six of a team-high nine targets for 69 yards while playing 52% of the offensive snaps. He came out of the game healthy and carries no injury designation into Monday night, which is the most important line in this writeup — a receiver this talented playing 50-plus percent of snaps with team-high volume is a strong signal his workload only climbs from here.

The matchup context favors him too: Los Angeles is dealing with secondary questions, and if the Giants need to throw to keep pace with the Rams’ offense, Nabers is Dart’s clear first read. He’s not the cheapest option on the board, but the target share and clean health report make him one of the safer WR plays on a slate that’s otherwise full of question marks at the position.

Isaiah Likely, TE — New York Giants ($7,400 DK)

Likely was arguably the biggest surprise of Week 1, hauling in 8 catches for 78 yards and two touchdowns on eight targets — second on the team in looks, with four of those targets coming in the red zone. That kind of red-zone role at tight end is exactly the profile that keeps producing regardless of whether the Giants are ahead or behind, since it’s one of the first things a rookie quarterback leans on near the goal line.

At $7,400, Likely is priced as a mid-range value rather than a premium tight end, which undersells the chemistry he’s already built with Dart. He’s a mismatch problem for opposing linebackers and safeties given his size, and with the Rams’ defense banged up in the secondary, there’s a real path to another multi-catch, red-zone-heavy performance. He’s the best combination of salary relief and legitimate upside on this slate.

Building Your Lineup

On a small slate like this, stacking is almost mandatory — pairing Dart with either Likely or Nabers gives you correlated upside if the Giants throw the ball 30-plus times, while rostering Kyren Williams alongside a Rams pass-catcher covers the other side of a potential blowout. Salary-wise, spending up on Dart and one of the two Giants pass-catchers, then balancing with Skattebo’s volume and Williams’ game-script edge, leaves a workable path to differentiate from the field.

Puka Nacua remains a question mark with a hip issue that kept him limited in practice, so treat him as a game-time-decision fade rather than a lock in cash lineups — if he’s active late, he becomes a pivot option, but building around him before an official status carries real risk. Matthew Stafford is also worth fading relative to his price; he struggled in Week 1 and doesn’t offer the same rushing floor that makes Dart so appealing at a similar salary. For DraftKings lineup builders and FanDuel picks alike, prioritizing the volume-and-role certainty of Dart, Skattebo, Williams, Nabers, and Likely gives you a foundation that should hold up whether this MNF showdown turns into a shootout or a Rams blowout.