Best NFL DFS Picks for Monday Night Football: Bills vs Rams

Monday Night Football closes out Week 5 with the Buffalo Bills traveling to SoFi Stadium to face the Los Angeles Rams, and this one carries real DFS appeal for a single-game slate. The Rams are implied for one of the highest point totals of the week at home, while Josh Allen and a desperate Bills offense will need to match scores after dropping a tight one to the Patriots. The latest live NFL odds have the total sitting at 54.5 points, with two offenses built to push tempo so game script shouldn’t force anyone into garbage-time mode early.

On a slate built around one matchup, the approach is simple: pay up for the players with the clearest paths to volume, then pair them with cheaper options who still have standalone roles. Here are five DFS picks worth building around for tonight’s DraftKings and FanDuel lineups.

Josh Allen, QB — Buffalo Bills ($7,400 DK / $9,100 FD)

Allen has been the engine of Buffalo’s offense through four games, completing 66.4% of his passes for 1,039 yards with six touchdowns and three interceptions, while adding a league-leading seven rushing touchdowns on 118 yards on the ground. That dual-threat rushing floor is what makes him a locked-in NFL DFS pick on almost any slate — even a rough outing through the air still leaves room for a goal-line score.

Last week against New England, Allen was held to 19.5 fantasy points in a 29-26 loss, but in the three games before that he posted 20.5, 40.8, and 38.7 points. The Rams’ defense ranks among the better units in the league overall, but Allen’s rushing floor gives him a game-script-proof outlook that’s hard to find at the position for Monday Night Football DFS. With DJ Moore banged up and questionable, expect the Bills to lean even more on Allen’s legs to manufacture points.

Kyren Williams, RB — Los Angeles Rams ($6,400 DK / $8,100 FD)

Williams has been one of the best all-around backs in football through four weeks, racking up 294 rushing yards and three touchdowns on 54 carries while adding 21 catches for 173 yards and another score through the air. He’s coming off a monster Week 4 against the Eagles — 16 carries for 80 yards and two touchdowns, plus a career-high 10 receptions for 67 yards on 13 targets.

That workload is the headline here: Williams has handled 83% of the Rams’ offensive snaps in recent weeks and has seen real volume in the passing game, which caps his downside even in a game where Los Angeles leans pass-heavy. With the Rams carrying the highest implied team total of any team on the Monday slate, Williams projects for plenty of red-zone work behind an offense that should be moving the ball consistently all night. He’s priced as a value relative to his workload and remains one of the safer DraftKings lineup building blocks for tonight.

Puka Nacua, WR — Los Angeles Rams ($7,800 DK / $9,100 FD)

Nacua is fully healthy and carries no injury designation into Monday night after missing time earlier this season with a hip and groin issue. In his return from that two-game absence last week against Philadelphia, he caught nine of 12 targets for 125 yards and a rushing touchdown while playing 90% of Los Angeles’s offensive snaps — a clear signal that the Rams plan to feed him volume right away.

The matchup only sweetens the appeal. Buffalo’s defense has been vulnerable on the back end, and Nacua profiles as one of the most talented wide receivers in the league whenever he’s on the field. Matthew Stafford has made him his primary read for most of his career in Los Angeles, and with a full week of practice behind him and an extra day of rest built into the Monday schedule, there’s little reason to expect the Rams to limit his workload. He’s a premium NFL DFS play at a premium price, but the target share makes the salary justifiable.

Dalton Kincaid, TE — Buffalo Bills ($5,100 DK)

Kincaid opened the season hot, posting a 5-130-0 line in Week 1 and following that with seven catches for 95 yards and a touchdown in Week 2. The role cooled over the past two weeks — just three catches for 45 yards on five targets combined in Weeks 3 and 4 — but with DJ Moore questionable and Joshua Palmer already ruled out with a shoulder injury, Buffalo’s receiving corps is thinning out heading into Monday night.

That opens the door for Kincaid to reclaim a larger share of Allen’s targets. He remains Allen’s most trusted red-zone option among the tight ends, and in a game both teams are expected to throw the ball plenty, a bounce-back line is well within reach. At a mid-range salary, Kincaid gives DFS players a path to touchdown upside at a position that’s often thin on a given week, making him a strong FanDuel picks consideration as well if Moore sits or is limited.

Keon Coleman, WR — Buffalo Bills ($4,600 DK)

Coleman has emerged as a reliable downfield threat for Buffalo over the past month, hauling in a 34-yard touchdown from Allen last week against the Patriots to go with a 21-yard catch on a contested “50-50” ball earlier in that same game. With DJ Moore questionable with a shoulder injury and Joshua Palmer already out, Coleman is positioned to see a notable bump in targets and snaps as one of Buffalo’s top remaining healthy wideouts.

At a sub-$5,000 DraftKings price tag, Coleman offers real touchdown equity in what should be a competitive, high-scoring environment. He’s shown chemistry with Allen on contested catches and deep shots, which matters in a game where the Rams’ secondary will be without a full complement of reps against Buffalo’s vertical passing concepts. He’s exactly the kind of MNF value play that rounds out a lineup without eating into cap space earmarked for the Rams’ top options. For bettors looking to back that same offensive spark on the sportsbook side, the DraftKings promo code is worth a look ahead of kickoff.

Building Your Lineup

On a single-game or limited slate like tonight’s, correlation matters more than usual. Pairing Nacua with Matthew Stafford gives you access to the Rams’ highest implied team total, while rostering Allen alongside either Kincaid or Coleman lets you capture Buffalo’s response if Los Angeles jumps ahead early. Williams is close to a must-play given his workload, which leaves the remaining salary to decide between stacking more of the Rams’ passing game or diversifying with Buffalo’s receiving options behind Moore’s questionable status.

Keep an eye on the final inactive list before kickoff — if DJ Moore sits, both Kincaid and Coleman see their target shares climb further, and that shifts some of the DraftKings lineup math in their favor. With a 54.5-point total and two offenses that have shown explosive-play ability all season, this is a game worth building multiple lineups around rather than fading entirely in favor of cheaper plays elsewhere on the board.