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NFL · GAME ODDS
ODDS UPDATE THROUGHOUT THE DAY

Detroit Lions @ Buffalo Bills

9/17

MONEYLINE
Lions+164
Bills-180
SPREAD
Lions +3.5-115
Bills -3.5-113
TOTAL
O 53.5-108
U 52.5-104

Best available price shown per line; odds refresh throughout the day and are subject to change.

Player Props

No player props currently available for this game.

Recent Form

Detroit Lions

DATE OPP CLOSE RESULT ATS/OU
Sep 13, 2026 New Orleans Saints -6 / 46.5 Won 31-30 Lost / Over
Jan 4, 2026 @Chicago Bears +3 / 51.5 Won 16-19 Won / Under
Dec 25, 2025 @Minnesota Vikings -7.5 / 45.5 Lost 23-10 Lost / Under
Dec 21, 2025 Pittsburgh Steelers -7.5 / 52.5 Lost 24-29 Lost / Over
Dec 14, 2025 @Los Angeles Rams +5.5 / 54.5 Lost 41-34 Lost / Over
Dec 5, 2025 Dallas Cowboys -3.5 / 55.5 Won 44-30 Won / Over
Nov 27, 2025 Green Bay Packers 48.5 Lost 24-31 — / Over
Nov 23, 2025 New York Giants -14.5 / 50.5 Won 34-27 Lost / Over
Nov 17, 2025 @Philadelphia Eagles +2.5 / 45.5 Lost 16-9 Lost / Under
Nov 9, 2025 @Washington Commanders -7.5 / 48.5 Won 22-44 Won / Over

Buffalo Bills

DATE OPP CLOSE RESULT ATS/OU
Sep 13, 2026 @Houston Texans +2.5 / 42.5 Won 31-36 Won / Over
Jan 4, 2026 New York Jets -13.5 / 39.5 Won 35-8 Won / Over
Dec 28, 2025 Philadelphia Eagles -3.5 / 45.5 Lost 12-13 Lost / Under
Dec 21, 2025 @Cleveland Browns -10.5 / 41.5 Won 20-23 Lost / Over
Dec 14, 2025 @New England Patriots -2.5 / 49.5 Won 31-35 Won / Over
Dec 7, 2025 Cincinnati Bengals -6 / 54.5 Won 39-34 Lost / Over
Nov 30, 2025 @Pittsburgh Steelers -3 / 44.5 Won 7-26 Won / Under
Nov 21, 2025 @Houston Texans -4.5 / 44.5 Lost 23-19 Lost / Under
Nov 16, 2025 Tampa Bay Buccaneers -6.5 / 44.5 Won 44-32 Won / Over
Nov 9, 2025 @Miami Dolphins -8.5 / 50.5 Lost 30-13 Lost / Under

DETROIT LIONS vs. BUFFALO BILLS Head-to-Head

Showing 3 of last 10 meetings

DATE TEAM OPP CLOSE RESULT ATS/OU
Dec 15, 2024 Detroit Lions @Buffalo Bills -2.5 / 55.5 Lost 42-48 Lost / Over
Nov 24, 2022 Detroit Lions @Buffalo Bills +9.5 / 54.5 Lost 25-28 Won / Under
Dec 16, 2018 Buffalo Bills @Detroit Lions -2.5 / 39.5 Won 14-13 Lost / Under