Terry McLaurin popped up on Washington’s injury report as a surprise addition Friday with a hamstring issue, and by Friday night the signs were pointing toward a Week 4 absence. The Commanders’ top wide receiver was limited in practice and is now considered likely to miss Sunday’s game against the Indianapolis Colts at Tottenham Hotspur Stadium in London, according to Ben Standig of The Athletic.

The timing could hardly be worse for Washington. The 1-2 Commanders are already without starting quarterback Jayden Daniels, who is sidelined with an elbow injury and has been ruled out, leaving Marcus Mariota to make his second straight start. Losing McLaurin on top of that would strip the offense of its most established weapon for a game being played nearly 3,700 miles from home.

How McLaurin’s Injury Developed

McLaurin was not on Washington’s injury report at all earlier in the week, making Friday’s addition a notable one. He was listed as a limited participant in practice with the hamstring injury and initially carried a questionable tag into the weekend. But as London travel and final roster decisions approached, the outlook shifted toward McLaurin sitting out, with Standig reporting he is “likely to miss” the Colts game. A hamstring injury surfacing for the first time on a Friday, rather than lingering from earlier in the week, is typically read as a cautionary sign for a player’s chances of suiting up just two days later.

If McLaurin is ruled out, Stefon Diggs and rookie Antonio Williams would step in as Washington’s top wide receiver options, with Dyami Brown and Treylon Burks also likely to see increased target share from Mariota. It would mark McLaurin’s first missed game of the season after he played through Washington’s first three contests.

McLaurin’s Season and Chemistry With Mariota

McLaurin enters Week 4 with 10 catches for 141 yards and a touchdown on 22 targets through three games, numbers he built almost entirely in Washington’s Week 3 upset win over the defending Super Bowl champion Seattle Seahawks. In that 33-31 victory, McLaurin caught six of nine targets for 77 yards and a touchdown, connecting with Mariota on a 30-yard score in the third quarter. It was easily his best outing of the season after a quiet start that saw him combine for just four catches on 13 targets for 64 yards across Washington’s first two games.

That Week 3 breakout came with Mariota under center rather than Daniels, and it continued a trend. McLaurin has played six games with Mariota at quarterback dating back to last season, and he has scored at least 14.4 PPR fantasy points in four of those six outings, suggesting real chemistry between the two even without Daniels on the field. Losing McLaurin now would remove the one receiver who has shown he can produce in this exact Mariota-led offense.

What It Means for the Colts-Commanders Betting Market

Indianapolis opened as a 3.5-point favorite over Washington for Sunday’s London matchup, and that number has held firm across the week even as the total has crept higher. The spread sits at Colts -3.5 to -4.5 depending on the book, with Indianapolis drawing roughly 88 percent of the betting money and 60 percent of tickets as of Friday, according to market tracking from WagerTalk. The total opened in the 46.5-47.5 range and has since climbed to as high as 48.5 at some books, with over bettors controlling the majority of money wagered on the game.

A McLaurin absence adds another layer to an already short-handed Washington passing attack that will already be operating without Daniels in a Mariota-led offense on the road against a Colts defense that has shown it can be attacked through the air. Removing Washington’s top target share earner from that equation — McLaurin carried a 23.1 percent target share on the season — puts more pressure on Diggs and the rookie Williams to produce against a defense that had allowed multiple receivers to top 12 PPR points per game entering Week 4. For bettors watching the Commanders moneyline, their season win total, or wide receiver props tied to Washington’s passing game, confirmation of McLaurin’s final status Sunday morning in London will be one of the most closely watched developments before kickoff.